The Ruger LCR is probably a good choice
And I would agree that .38 Special ammunition is easier to handle than .22 rimfire. In the low-recoil department, there's still the old standby: .38 wadcutters (factory/match), so that base remains well covered.
Others mention the tip-up .380s, but I happen to have limited hand strength myself, and I would rather be consigned to practicing DA-Dryfire-In-Hades than have to load most .380 magazines even once. FWIW, I think people *read* a lot of magazines, but to their good fortune, they never actually experience these things.
I also think everything else (gun included, for that matter) would probably have to be tried by the individual in order to determine whether it would work for him. For example, I have fairly large hands, so the smaller CT Laser Grips for S&W J-frames don't fit me at all because there is nowhere near enough room behind the trigger guard. Sights are similarly 'personal' in terms of choice: I happen to like the XS Big Dot, but many do not.
Long story short: Take the man to the gun shop (and, if possible, the range), and go from there.
HTH 
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Complete thread:
- Ruger LCR 38 Special For The Elderly? - 
~JM~, 
2013-05-23, 19:25 
- Ruger LCR 38 Special For The Elderly? - RidinLou, 2013-05-23, 19:46
 - Ruger LCR 38 Special For The Elderly? BERETTA 86 - cable, 2013-05-23, 20:05
 - They are pricey but have you thought of a Beretta 84 380? - 
stonewalrus, 
2013-05-23, 20:07
- i believe it is the only beretta 86 with the tip up barrel - 
cable, 
2013-05-23, 21:17
- You may be right on the number I wasn't sure - stonewalrus, 2013-05-24, 13:04
 
 
 - i believe it is the only beretta 86 with the tip up barrel - 
cable, 
2013-05-23, 21:17
 - The Ruger LCR is probably a good choice - FOG, 2013-05-23, 20:46
 - Ruger LCR 38 Special For The Elderly? - 
anachronism, 
2013-05-23, 22:06
- Ruger LCR 38 Special For The Elderly? - 
Catoosa, 
2013-05-23, 23:11
- Ruger LCR 38 Special For The Elderly? - anachronism, 2013-05-24, 18:53
 
 
 - Ruger LCR 38 Special For The Elderly? - 
Catoosa, 
2013-05-23, 23:11
 - Ruger LCR 38 Special For The Elderly? - 
~JM~, 
2013-05-24, 07:51
- Given those options and limitations, I'd say get the LCR - FOG, 2013-05-26, 15:09
 
 - The triggers are smooth and light for a DAO. (nm) - 
Boge Quinn, 
2013-05-24, 09:35
- That is true. People who try all the models we have - Hobie, 2013-05-24, 13:11
 
 - consider a pair of pistols, so racking slides reloading etc - Rob Leahy, 2013-05-24, 10:40
 - Check Bruce Eimer's articles at this link - DeeBee, 2013-05-24, 19:23
 - Ruger LCR 38 Special For The Elderly? - stonewalrus, 2013-05-24, 22:18
 - I have one, it ain't bad ... - Flatlander, 2013-05-26, 18:08
 - One more thing - 
FOG, 
2013-05-28, 03:15
- Well I Checked Out One LCR in 357.... - ~JM~, 2013-05-28, 09:05